WHAT WE DO
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Micro Bioreactor
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Glass Bioreactor Fermenter
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Stainless Steel Bioreactor Fermenter
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Multiple Glass Bioreactor
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Multiple Multistage Stainless Steel Fermenter
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Cell Bioreactor Fermenters
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Advanced Bioreactor Fermenter
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Airlift Bioreactor Fermenter
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Solid State Fermenter
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Pilot Production Bioreactor
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Biopharmaceutical Process Module
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WAVE Bioreactor
FEATURES PRODUCTS
PROJECT CASE
Henan Fengxian Technology Co., Ltd. has a large number of experienced fermentation processes, and has provided bioreactor systems for more than 50 countries around the world, and has accumulated rich experience in bioreactor engineering such as design, production, installation, and commissioning. Our equipment parts use standard parts as much as possible, and the key parts are basically consistent with European products to ensure the quality of the products, and at the same time optimize the pipeline, facilitate maintenance and maintenance during operation, and reduce the use cost of customers.
ABOUT US
- Rigorous
- Easy
- Innovation
- Stability
Henan Fengxian Technology Co., Ltd. is a manufacturer and technical service provider specializing in complete solutions of bioreactors. Has 15 years of experience in fermentation process research and fermentation equipment manufacturing. We focuses on the biopharmaceutical and bioengineering industries, and its production services include: R&D, design, manufacturing and verification of high-standard sanitary containers and modular process equipment; installation and verification services in pharmaceutical factories/workshops; biological and pharmaceutical engineering design and consulting Service; Committed to becoming a leading provider of overall solutions for biopharmaceutical engineering in China. Our bioreactors are mainly used for Escherichia coli, yeast, fungi, insect cells, plant cells and animal cell culture, etc. The application fields include medical vaccines, animal vaccines, antibodies, microbial fermentation, cell tissue engineering, stem cell culture, recombinant protein drugs It can also be used as a production-scale fermenter for laboratory-level research and pilot trials such as , antibiotics, enzymes, and biofuels.
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- 15YRS
Biological Fermentation
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- 130PPL
Research & Design
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- 20000SQM
Industrial Plant
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- 7X24HRS
Technical Support
BIOREACTOR FERMENTER VIDEOS
LEARN ABOUT BIOREACTOR
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Analysis Of The Advantages And Disadvantages Of The Five Major Valves
There are many types of valves, each with its own advantages and disadvantages. Here are the advantages and disadvantages of the five major valves, including gate valves, butterfly valves, ball valves, globe valves and plug valves. I hope it will be helpful to you. 1. Gate valve Gate valve refers to a valve whose closing member gate moves along the vertical direction of the channel axis. It is mainly used to cut off the medium on the pipeline, that is, it is used fully open or fully closed. Generally, gate valves cannot be used to regulate flow. It can be applied to low temperature pressure or high temperature and high pressure, and can be used according to different materials of the valve. However, gate valves are generally not used in pipelines transporting media such as mud. advantage: ①After the gate valve is opened, the medium channel inside the valve body is straight without any obstruction, and the flow resistance is very small. ② When opening and closing, the movement direction of the gate plate of the gate valve is perpendicular to the direction of medium flow, the pressure is small, and opening and closing is less labor-intensive. ③The height of the gate valve is large, so the opening and closing time is longer, and water hammer is not prone to occur. ④ Both sides of the gate valve channel are symmetrical, and the medium can flow in any direction on both sides, so the installation of the gate valve is very convenient. ⑤Short structural length, good manufacturing process, and wide application range. ⑥The structure length is relatively short. shortcoming: ①The sealing surface of the gate valve is very easy to wear, which affects the service life of the valve and is more troublesome to repair. ② The structure of the... -
Α-Arbutin | New Ideas For High-yield Biocatalysis
Alpha-arbutin, an alpha-glucoside extracted from hydrobenzoquinone, blocks melanin synthesis by effectively inhibiting the tyrosinase activity of melanocytes and is known for its major whitening properties. Furthermore, α-arbutin exhibits high antioxidant, antimicrobial, and anti-inflammatory activities and is widely used in the pharmaceutical and cosmetic industries. Professor Liu Long’s team from Jiangnan University’s Key Laboratory of Glycochemistry and Biotechnology of the Ministry of Education published an article in "Applied microbiology and biotechnology": "Combinatorial metabolic engineering enables high yield production of α-arbutin from sucrose by biocatalysis", through knockout and sucrose hydrolysis Genes related to the enzyme increase the sucrose conversion rate to 51.5%. An inducible protein degradation system was also developed, using Lon protease and proteolytic tag to control the activity of PfkA, thereby converting more fructose-6-phosphate into glucose-1-phosphate for α-arbutin synthesis. And by integrating another copy of 6-phosphate glucose isomerase and phosphate glucose decomposing enzyme, the pathway from F6P to Glc1P was strengthened, a high α-arbutin titer was obtained, and the sucrose conversion rate was increased to 60.4%. In this study, substrate utilization was improved due to the attenuation of hydrolysis and the assistance of intracellular enzymes that reconvert the by-products into substrates for α-arbutin synthesis. This strategy provides a new idea for whole-cell biocatalytic synthesis of other products using sucrose as a substrate, especially valuable sugars. α-Arbutin has previously been produced by chemical synthesis and biotransformation. Among them, the chemical synthesis of α-arbutin requires the protection and deprotection of the OH group due to the harsh reaction conditions and complex reaction process. In contrast, biotransformation of α-arbutin was considered as a potential candidate. Because its synthesis procedures are simpler, the reaction conditions are mild, and there is less pollution, including enzymatic conversion, microbial fermentation, and whole-cell biocatalysis. Whole-cell biocatalysis of α-arbutin was performed by engineered microbial cells expressing glycosyltransferases from different... -
Key Parameter In Bioreactor Cell Culture: Dissolved Oxygen
In the biological reaction production process, the DO value is generally used as the dissolved oxygen parameter. The DO value is one of the most critical parameters in the entire fermentation process. It can not only intuitively reflect the dynamic changes of the entire fermentation process, but also indirectly reduce fermentation production time and energy consumption by increasing the DO value, and improve the yield and quality of the final product. Dissolved oxygen is one of the most important parameters for aerobic fermentation control. Since the solubility of oxygen in water is very small, and the solubility in fermentation broth is even smaller, ventilation and stirring need to be constantly adjusted to meet the oxygen needs of different fermentation processes. The size of dissolved oxygen will have different effects on bacterial growth and product formation and yield. Here, we will introduce the changes in dissolved oxygen concentration in different periods, the reasons for the abnormal decrease/increase in dissolved oxygen, and aspects of oxygen supply and oxygen consumption. Changes in dissolved oxygen concentration During the fermentation process, under certain fermentation conditions, the dissolved oxygen concentration of each fermentation product has its own rules. Generally, changes in dissolved oxygen concentration occur in three stages. In the logarithmic growth phase, the DO value drops significantly, and the growth of the bacteria can be roughly estimated from the rate of decline; at the end of the logarithmic growth phase, there will be a low point in dissolved oxygen; in the later stage of fermentation, due to the aging of the bacteria, the respiration intensity weakens, The dissolved oxygen concentration will also gradually increase. Once the bacteria autolyze, the increase in dissolved oxygen concentration will be more obvious. Causes of abnormal decrease/increase in dissolved oxygen During the fermentation process, sometimes there will be abnormal changes...